Endocrine Abstracts

Background and aims: Non alcoholic fatty liver disease (NAFLD) is highly associated with other components of the metabolic syndrome, in particular obesity and diabetes. However, systematic network medicine approach of the complex phenotypic dependencies and comorbidities has yet to be performed. Our aim now is to identify novel drug targets for NAFLD treatment by a systematic in silico network analysis.Methods: We constructed an interaction network of cu...

Introduction: Primary aldosteronism (PA) occurs due to an excess production of aldosterone in the adrenal glands, resulting in low renin levels and hypertension. Familial hyperaldosteronism is considered to be a relatively rare disorder, with only a small number of genes having been implicated so far. The aim of the present study is to identify the molecular cause of disease in a PA family, as well as examining the mechanisms in an in vitro setting.<p class="abste...